GREAT PLAINS LABORATORIES:
Great Plains Laboratories specializes in identifying organic acids which are eliminated by the kidney and expelled in the urine. Organic acids are protein based reactive compounds often linked to a sulfur, phosphorous, or nitrogen molecule, and are normally synthesized in the cell’s mitochondria.
Abnormal accumulations of organic acids are often intermediary metabolic products that can accumulate when there is significant disruption of metabolic pathways. These examples include glucose catabolism (glycolysis), glycation end products (AGEs), glucose synthesis (gluconeogenesis), amino acid and ammonia metabolism, and purine and pyrimidine metabolism. Intern, these can adversely affect our neurotransmitters, hormones, immune system, protein and fat metabolism. These compounds are not only produced by our own bodies, but they are also a part of the metabolism of our non-human biome (bacteria, virus, yeast, fungi and parasites). Urinary excretion of abnormal organic acid metabolites can cause, or signal, inflamed leaky gut, lung, and/or brain syndromes. Even patients with rare genetic disorders, who develop pathological accumulation of intermediate metabolites (incompletely formed, non or partially active proteins/enzymes), can be identified by this type of testing. This test will also pick up problems with interference in our neurotransmitters (e.g epinephrine, norepinephrine, dopamine, and serotonin) and our hormones, as well as from environmental toxins. Urine is easy to collect and therefore no blood test is required, and you can do this from your home and send it the lab using the enclosed FedEx envelope.
For more information: https://www.greatplainslaboratory.com/organic-acids-test
A 68-year-old retired female who complains of irregular heartbeats, insomnia and anxiety. This organic acid test (OAT) reflects the levels of non-human, bacterial, yeast and fungal proteins that leaked from her gut into the venous drainage of her colon and are subsequently excreted by her kidneys. This study establishes her leaky gut condition and identifies a dysbiosis of her microbiome (the genetic material of all the microbes, bacteria, fungi, protozoa and viruses that live on and inside the human body). The metabolic products from certain species of Clostridia interfere with her normal enzyme (DBH) which results in a decrease of her normal dopamine levels. This can lead to diffuse anxiety. This type of testing is very helpful to identify and correctly treat root causes of behavioral disorders which are not identified by psychiatric techniques.
For more information see the link below:
https:// www .ncbi.nlm.nih.gov/gene/1621