Case 5: Premenopausal Symptoms


Labrix/Doctor Data Inc specializes in hormone and neurotransmitter balance for males and females. This laboratory uses saliva and urine samples you collect at specific times throughout the day to obtain a full spectrum of hormone/neurotransmitters over the entire 24-hour collection period. This process offers a more comprehensive evaluation than a single blood sample drawn in a lab. You collect the samples at home using the kit provided and return them to the laboratory in the enclosed FedEx prepaid mailer.

For more information:

A 44-year old perimenopausal real estate agent with complaints of loss of energy, insomnia, irritability, anxiety, stress, thinning skin, mood swings, food cravings, dry hair, brittle nails, and difficulty focusing. Her other established medical issues include hypertension, obesity, and Type 2 Diabetes. She does not have any hot flashes or night sweats.

Her 24-hour cortisol response curve shows a “pancake sign” which is diagnostic of the degree of overall stress. The Cortisol Awakening Response (CAR) test is the only physiological parameter that has been clinically useful to document stress: the emotional response the body has when it encounters any stimulus (physical or mental) that it is not prepared to handle. Cortisol is the “fight or flight” hormone which prepares the body for stress by increasing energy levels (raises glucose and insulin levels, releases adrenaline, and generates greater central vision acuity). Under normal circumstances, cortisol is decreased at night and increases rapidly after the optic nerve detects daylight at sunrise. Normally cortisol levels increase >50 from baseline in the first 40 minutes after awakening. Failure to achieve this level or rise is the indicator we used to measure the perceived level of stress as you face the new day. This patient has a flat (“pancake”) response throughout the 24 hour period, which corresponds to her loss of energy and fatigue.

For more information about CAR: